Transcription Factor-Mediated Reprogramming of Cancer-Associated Fibroblasts Reveals Targetable Vulnerabilities in Solid Tumors
Nan Sook Lee, Priyankan Datta, Yixuan Huang, Bella Raykowski, Xi Yu, Tianze Guo, Peixiang He, Sreejesh Moolayadukkam, Ben Yi Tew, Shigang Xiong, Chi Woo Yoon, Yingxiao Wang, Christopher C. DeRenzo, Jacek Pinski, Ishwar K. Puri
This study reprograms cancer-associated fibroblasts using transcription factors to reduce therapy resistance and enhance CAR T cell efficacy in solid tumors.
bioRxiv · Apr 20, 2026 · PreprintCancer Biology