Structural visualisation of the dynamics of DNA unwinding by a replicative helicase
Taha Shahid, Muhammad Tehseen, Lubna Alhudhali, Alice Clark, Christos G. Savva, Samir M. Hamdan, Alfredo De Biasio
This study uses cryo-EM to visualize the dynamics of DNA unwinding by the SV40 Large Tumor Antigen helicase, revealing how ATP hydrolysis drives translocation and strand separation.
bioRxiv · Apr 19, 2024 · PreprintBiophysics