Christos G. Savva

This study presents a cryo-EM structure of the human CTF18-RFC complex bound to PCNA, revealing structural features important for PCNA loading and Pol ε-mediated leading strand synthesis.

This study identifies an E3-HTL-substrate complex that reveals how strigolactone perception by the receptor HTL7 is linked to substrate recognition by the E3 ubiquitin ligase MAX2.

This study uses cryo-EM to visualize the dynamics of DNA unwinding by the SV40 Large Tumor Antigen helicase, revealing how ATP hydrolysis drives translocation and strand separation.

This paper reports the cryoEM structure of M. tuberculosis Pks13, revealing its homodimeric architecture and providing insights into its catalytic mechanism.

The paper uses Cryo-EM to determine the structure of Aquifex aeolicus lumazine synthase at 1.42 Angstrom resolution, revealing hydrogen atoms and confirming near-atomic resolution for protein complexes.