Characterization of natural product inhibitors of quorum sensing in Pseudomonas aeruginosa reveals competitive inhibition of RhlR by ortho-vanillin
Kathryn E. Woods, Sana Akhter, Blanca Rodriguez, Kade A. Townsend, Nathan Smith, Ben Smith, Alice Wambua, Vaughn D. Craddock, Rhea G. Abisado, Emma E. Santa, Daniel E. Manson, Berl R. Oakley, Lynn E. Hancock, Yinglong Miao, Helen E. Blackwell, Josephine R. Chandler
This study evaluates benzaldehyde derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa, identifying ortho-vanillin as a competitive inhibitor of RhlR.
Microbiology Spectrum · Jul 24, 2024Peer-reviewedMicrobiology