Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges
Shalakha Hegde, Sana Akhter, Zhichao Tang, Chang Qi, Chenguang Yu, Anna Lewicka, Yu Liu, Kushal Koirala, Mikhail Reibarkh, K.P. Battaile, Anne Cooper, S. Lovell, Erik D. Holmstrom, Xiao Wang, Joseph A. Piccirilli, , Jingxin Wang
This study identifies coumarin derivatives that selectively bind RNA single G bulges, revealing key structural features and using computational and experimental methods to guide rational ligand design.
Nucleic Acids Research · Jun 5, 2025Peer-reviewedBiochemistry