Phased Diploid Genome Assembly with Single Molecule Real-Time Sequencing
Chen-Shan Chin, Paul Peluso, Fritz J. Sedlazeck, Maria Nattestad, Gregory T. Concepcion, Alicia Clum, Christopher Dunn, Ronan O'Malley, Rosa Figueroa-Balderas, Abraham Morales-Cruz, Grant R. Cramer, Massimo Delledonne, Chongyuan Luo, Joseph R. Ecker, Dario Cantu, , Michael C. Schatz
This paper introduces FALCON and FALCON-Unzip algorithms to assemble diploid genomes from SMRT sequencing data, demonstrating improved contiguity and phasing compared to short-read methods.
bioRxiv · Jun 3, 2016Bioinformatics