EBV INFECTION OUTCOMES DETERMINED BY MONOCYTE AND TREG-DRIVEN IMMUNE DYNAMICS IN AN EX VIVO PBMC MODEL
Leena Yoon, Lauren N. MacMullen, Leonardo Josué Castro-Muñoz, Alina Gu, Jamie Bregman, Mary Campion, Avi Srivastava, Rena R. Xian, Richard F. Ambinder, Andrew V. Kossenkov, Samantha S. Soldan, Paul M. Lieberman
This study uses an ex vivo PBMC model to show that monocyte and Treg dynamics determine EBV infection outcomes, with LIPA and Tregs playing key roles in antiviral responses and LCL outgrowth.
bioRxiv · Nov 20, 2025 · PreprintImmunology