Aβ oligomers induce sex-selective differences in mGluR5 pharmacology and pathophysiological signaling in Alzheimer mice
Khaled S. Abd‐Elrahman, Awatif B. Albaker, Jéssica M. de Souza, Fabiola Mara Ribeiro, Michael G. Schlossmacher, Mario Tiberi, Alison Hamilton, Stephen S. G. Ferguson
This study shows that mGluR5 pharmacology and Aβ oligomer-induced signaling differ between male and female Alzheimer's mice, with implications for sex-tailored treatments.
bioRxiv · Jun 10, 2020 · PreprintNeuroscience