Khaled S. Abd‐Elrahman

This study shows that activating M1 mAChR with VU0486846 restores neurovascular coupling deficits in tauopathy mice, with sex-specific effects.

This study identifies TRIM9 as a sex-specific regulator of the Aβ42/PrPC/mGluR5 complex in male Alzheimer's mice, linking it to pathological signaling and autophagy.

This paper introduces a protocol to generate sex-specific, high-purity astrocyte cultures from single neonatal mouse brains, avoiding the need for tissue pooling.

This paper uses membrane-mimetic proteomics to show that AD-related membrane proteome changes are enriched in APP mice, and M1 receptor activation selectively affects disease-altered membrane networks.

This study shows that mGluR5 pharmacology and Aβ oligomer-induced signaling differ between male and female Alzheimer's mice, with implications for sex-tailored treatments.