Author

Stephen S. G. Ferguson

University of OttawaORCID 0000-0002-0887-7312Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Khaled S. Abd‐ElrahmaniD· 3 shared Fatemeh BabaeiiD· 2 shared Fatemeh Panahi Arasi· 2 shared Mario TiberiiD· 2 shared Tash‐Lynn L. ColsoniD· 2 shared Alison Hamilton· 1 shared Ashim BhattacharyaiD· 1 shared Awatif B. AlbakeriD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Khaled S. Abd‐ElrahmanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

β-Arrestin2 Drives Sex-Specific Akt/GSK3β Signaling, Aβ Pathology, and Cognitive Decline in Alzheimers Disease Mice

Fatemeh Panahi Arasi, Fatemeh Babaei, Tash‐Lynn L. Colson, Stephen S. G. Ferguson

This study shows that β-arrestin2 deficiency has sex-specific effects on Aβ pathology, cognition, and autophagy in Alzheimer's disease mice, with male-specific reductions in pathology and cognitive decline.

bioRxiv · Aug 18, 2026 · PreprintNeuroscience

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer's Disease Mice

Fatemeh Babaei, Fatemeh Panahi Arasi, Tash‐Lynn L. Colson, Hang Cheng, Mario Tiberi, Rony Chidiac, Stéphane Angers, Stephanie L. Gupton, Khaled S. Abd‐Elrahman, Stephen S. G. Ferguson

This study identifies TRIM9 as a sex-specific regulator of the Aβ42/PrPC/mGluR5 complex in male Alzheimer's mice, linking it to pathological signaling and autophagy.

bioRxiv · Aug 4, 2026 · PreprintNeuroscience

Membrane Proteome Remodeling in Female APP Mice Following Muscarinic Acetylcholine Receptor M1 Modulation Revealed by Peptidisc Enabled DIA-MS.

Ashim Bhattacharya, Frank Antony, Hiroyuki Aoki, Mohan Babu, Stephen S. G. Ferguson, Khaled S. Abd‐Elrahman, Franck Duong

This paper uses membrane-mimetic proteomics to show that AD-related membrane proteome changes are enriched in APP mice, and M1 receptor activation selectively affects disease-altered membrane networks.

bioRxiv · Feb 27, 2026 · PreprintBiochemistry

Aβ oligomers induce sex-selective differences in mGluR5 pharmacology and pathophysiological signaling in Alzheimer mice

Khaled S. Abd‐Elrahman, Awatif B. Albaker, Jéssica M. de Souza, Fabiola Mara Ribeiro, Michael G. Schlossmacher, Mario Tiberi, Alison Hamilton, Stephen S. G. Ferguson

This study shows that mGluR5 pharmacology and Aβ oligomer-induced signaling differ between male and female Alzheimer's mice, with implications for sex-tailored treatments.

bioRxiv · Jun 10, 2020 · PreprintNeuroscience