GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A
Sarah Reem Akaaboune, Aadil Javed, Sarah Bui, Alissa Wierenga, Yanzhuang Wang
This study shows GRASP55 regulates lysosomal enzyme trafficking by affecting HEXA sorting, M6P receptor interaction, and GNPTAB expression, leading to altered enzyme maturation and secretion.
Molecular Biology of the Cell · Jan 22, 2025Peer-reviewedCell Biology