Improved gene targeting in vivo using EoHR, a small molecule inhibitor of 53BP1
Sarah J. Spencer, Finn O’Donoghue, Angelina Ristovski, Astrid Glaser, Subashani Maniam, Mitra Mohsenipour, Alita Soch, Andrew J. Deans, Stephen J. Headey
This paper introduces EoHR, a 53BP1 inhibitor that enhances HDR efficiency in Cas9-mediated gene editing in mice, doubling successful edits and reducing time to project success.
bioRxiv · May 30, 2024 · PreprintBiochemistry