BiochemistrybioRxivPreprint
Improved gene targeting in vivo using EoHR, a small molecule inhibitor of 53BP1
Sarah J. Spencer, Finn O’Donoghue, Angelina Ristovski…·Stephen J. Headey
This paper introduces EoHR, a 53BP1 inhibitor that enhances HDR efficiency in Cas9-mediated gene editing in mice, doubling successful edits and reducing time to project success.
DOI 10.1101/2024.05.30.596757