Carborane-NHS esters as versatile reagents for amine-selective small-molecule modification, bioconjugation, and peptide-polymer assembly
Anze Jenko, Urban Barbic, Aljaz Renko, Ching‐Pei Hsu, Dane Jemc, Spela Makuc, Lana Jamnik, Vera Župunski, Andrei Loas, Bradley L. Pentelute, Martin Gazvoda
This paper develops carborane-NHS ester reagents for selective amine modification of biomolecules, demonstrating their use in conjugating antibodies with carboranes for boron neutron capture therapy.
bioRxiv · Oct 24, 2025 · PreprintBiochemistry