Andrei Loas

This paper develops carborane-NHS ester reagents for selective amine modification of biomolecules, demonstrating their use in conjugating antibodies with carboranes for boron neutron capture therapy.

This paper develops an in vivo method to covalently link peptide drugs to native IgGs, demonstrating sustained weight loss and glucose management with GLP-1.

This paper develops a PNA-peptide conjugate targeting miRNA-21 in mouse tissues, showing improved cardiac delivery and inhibition compared to PNA alone.

This paper develops branched multimeric peptides that bind α-Klotho with high affinity and selectivity, enabling its detection and labeling in biological systems.

The paper synthesizes a 217 amino acid-long N-terminal domain of pyocin S2 using automated fast-flow peptide synthesis, achieving rapid production and selective uptake in Pseudomonas aeruginosa.

The paper designs a covalent peptide inhibitor, reactide, targeting the HPV16 E6-E6AP interaction to prevent p53 degradation.

Deep learning generates de novo large functional abiotic polymers that deliver antisense oligonucleotides to the nucleus.