Knockdown of endogenous circulating C1 inhibitor induces neurovascular impairment, neuroinflammation and cognitive decline
Dorit Farfara, Emily R. Feierman, Allison T. Richards, Alexey S. Revenko, Robert A. MacLeod, Erin H. Norris, Sidney Strickland
This study shows that reducing C1INH in mice causes neurovascular issues, inflammation, and cognitive decline by activating the kallikrein-kinin system.
bioRxiv · May 21, 2018 · PreprintNeuroscience