Emily R. Feierman

Mechanisms controlling the deposition and dynamics of histone variant H2BE

This paper identifies key factors regulating H2BE incorporation, localization, and eviction in neuronal chromatin, revealing chaperones and complexes involved in its dynamics.

Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain

The paper introduces spatial NT-seq to map RNA turnover and stability in the mouse brain, revealing spatial heterogeneity and kinetics scaling mechanisms in response to ECS.

Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling

This study shows that H2BE is required for activity-dependent gene expression and homeostatic scaling in neurons.

Intracellular Protein Editing to Enable Incorporation of Non-Canonical Residues into Endogenous Proteins

This paper introduces a protein editing technology that enables site-specific insertion of non-canonical residues into endogenous proteins in live mammalian cells.

Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory

This study identifies H2BE as a widely expressed H2B variant that enhances chromatin accessibility in neurons, promoting synaptic gene expression and long-term memory.

Knockdown of endogenous circulating C1 inhibitor induces neurovascular impairment, neuroinflammation and cognitive decline

This study shows that reducing C1INH in mice causes neurovascular issues, inflammation, and cognitive decline by activating the kallikrein-kinin system.