Alexey S. Revenko

Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA MALAT1 in breast cancer progression

This study evaluates MALAT1-targeting ASOs in breast cancer using patient-derived organoid models, showing MALAT1's role in alternative splicing, metastasis, and tumor-stroma interactions.

EPHA2 and scavenger receptor-directed trafficking enhances endosomal leakiness and antisense therapy delivery

This study identifies a mechanism by which antisense oligonucleotides (ASOs) enter cells via scavenger receptors and EPHA2-mediated trafficking to reach nuclear-adjacent endosomes, enhancing their effectiveness.

Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice

This study shows that prothrombin prevents fatal T cell-dependent anemia in mice during chronic viral infection by reducing hemolysis, not by affecting T cell function or viral load.

Knockdown of endogenous circulating C1 inhibitor induces neurovascular impairment, neuroinflammation and cognitive decline

This study shows that reducing C1INH in mice causes neurovascular issues, inflammation, and cognitive decline by activating the kallikrein-kinin system.