DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
Abd-El-Monsif Shawky, Allison V. Eckhardt, Josef B Mick, Mahmoud F. Dondeti, Kenneth Avanzino, Constantine A. Simintiras, Maria Hatzoglou, Anastassios Vourekas
The paper identifies DDX3X as a dual switch regulator of mRNA translation, promoting or suppressing translation in non-stressed cells and switching roles in acute ER stress.
Cell Reports · Oct 29, 2025Peer-reviewedMolecular Biology