Interaction of modified oligonucleotides with nuclear proteins, formation of novel nuclear structures and sequence-independent effects on RNA processing
Loren L. Flynn, Ruohan Li, May Thandar Aung-Htut, Ianthe L. Pitout, Jack A. L. Cooper, Alysia Hubbard, Lisa Griffiths, Charles S. Bond, Steve Donald Wilton, Archa H. Fox, Sue Fletcher
This study investigates how modified oligonucleotides affect nuclear structures and RNA processing, finding that phosphorothioate backbones cause subnuclear disruptions and RNA processing changes.
bioRxiv · Mar 4, 2019 · PreprintMolecular Biology