Archa H. Fox

PICARD-seq enables rapid, affordable whole-plasmid sequencing using nanopore technology, improving accuracy and resolving repetitive regions in synthetic constructs.

This paper reports covalent ligands targeting the RNA-binding protein NONO, showing they stabilize mRNA interactions, remodel transcriptomes, and suppress cancer cell growth with high specificity.

The paper maps human nuclear bodies using proximity proteomics, identifying new components and regulatory functions in RNA regulation.

This study identifies distinct roles of low-complexity regions in SFPQ for biomolecular condensate formation, showing the C-terminal region drives condensation while the N-terminal region inhibits it.

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

The paper investigates paraspeckle formation in naked mole-rats, finding that nNEAT1_2 recruits different RNA binding proteins compared to mice.

This study investigates how modified oligonucleotides affect nuclear structures and RNA processing, finding that phosphorothioate backbones cause subnuclear disruptions and RNA processing changes.