Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72
Noori Chai, Michael Seamus Haney, Julien Couthouis, David W. Morgens, Alyssa Benjamin, Kathryn Wu, James A. Ousey, Shirleen Fang, Sarah Finer, Michael Cory Bassik, Aaron D. Gitler
The paper identifies FIS1 as a genetic interactor of C9ORF72 through a synthetic lethal CRISPR screen in human myeloid cells, revealing a role for FIS1 in suppressing inflammatory signaling.
Brain Research · Dec 13, 2019Peer-reviewedNeuroscience