Kathryn Wu

This study shows actin disassembly enables myelin compaction and wrapping in the CNS by developing live-cell assays and genetic perturbations.

This study identifies VAMP2/3-mediated exocytosis as essential for CNS myelin membrane expansion, revealing a pathway critical for myelin formation and potential therapeutic targeting.

The paper uses single-cell RNA-seq to identify early ALS signatures in iPSC-derived motor neurons across multiple models and platforms.

The paper identifies FIS1 as a genetic interactor of C9ORF72 through a synthetic lethal CRISPR screen in human myeloid cells, revealing a role for FIS1 in suppressing inflammatory signaling.