Michael Seamus Haney

The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.

This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

The paper identifies lipid droplet-accumulating microglia (LAM) as a dysfunctional, pro-inflammatory state in aging brains, linked to neurodegeneration.

The paper identifies FIS1 as a genetic interactor of C9ORF72 through a synthetic lethal CRISPR screen in human myeloid cells, revealing a role for FIS1 in suppressing inflammatory signaling.

The paper provides a comprehensive whole-genome analysis of K562, identifying genomic structural features and their impact on functional genomics data.

The paper investigates how large genomic deletions affect chromatin interactions and states in human brain development using Hi-C and ChIP-Seq analyses.

Genome-wide CRISPR-Cas9 screens in human cells reveal mechanisms and targets for ALS-associated C9orf72 dipeptide repeat protein toxicity.