Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition
Akie Fujita, Sooyeon Jo, Robert G. Stewart, Tomás Osorno, Alyssa Ferraiuolo, Kevin P. Carlin, Bruce P. Bean
This study compares the effects of Nav1.7 and Nav1.8 inhibitors on human dorsal root ganglion neuron excitability, finding Nav1.7 inhibition has larger effects on action potential threshold and upstroke velocity but less impact on repetitive firing.
eLife · Oct 23, 2026Peer-reviewedNeuroscience