Bruce P. Bean

Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition

This study compares the effects of Nav1.7 and Nav1.8 inhibitors on human dorsal root ganglion neuron excitability, finding Nav1.7 inhibition has larger effects on action potential threshold and upstroke velocity but less impact on repetitive firing.

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media

This paper introduces a method to preserve human dorsal root ganglion neurons using Hibernate media, enabling easier access and transport for research.

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells

This paper describes a method to efficiently generate human sensory neurons from pluripotent stem cells for drug development.

Cannabidiol activates neuronal Kv7 channels

This study identifies CBD's activation of Kv7 channels as a mechanism for its antiepileptic effects.

Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker

This paper develops a novel cationic compound, BW-031, that effectively inhibits cough by targeting large pore-expressing airway sensory neurons through aerosolized delivery.

Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain

This paper shows anthrax toxin can target and modulate pain by acting on nociceptive neurons through ANTXR2, with potential for new pain therapeutics.