Squamous-state excursions activate APOBEC3A in cancer
Josefine Striepen, Alexandra Dananberg, Aušrinė Ruzgaitė, Alyssa Hurley, Eléonore Toufektchan, Ashley Nichols, Hannah Rosenberg, Cameron Cordero, Tony M. Mertz, R. M. Norman, Richard P. Koche, Steven A. Roberts, John Maciejowski
The paper identifies transient squamous-state excursions in cancer cells as a source of APOBEC3A mutagenesis, linking it to lineage-state plasticity rather than persistent inflammation.
bioRxiv · May 26, 2026 · PreprintCancer Biology