Josefine Striepen

This study identifies heterogeneous roles of APOBEC3A and APOBEC3B in lung adenocarcinoma mutagenesis using CRISPR-Cas9 and whole-genome sequencing of single-cell clones.

The paper identifies transient squamous-state excursions in cancer cells as a source of APOBEC3A mutagenesis, linking it to lineage-state plasticity rather than persistent inflammation.

This study identifies new antimalarial compounds targeting PfATP4 through phenotypic screening, showing fast-killing activity and resistance patterns consistent with PfATP4 inhibition.

This study identifies APOBEC3B as the enzyme responsible for ssDNA breakage during replication catastrophe induced by ATR inhibition, revealing a mechanism for PARP1 trapping and synthetic lethality with PARP inhibitors.

The paper shows that ecDNA inheritance is ensured through mitotic transcription and chromosomal tethering via BRD4 and PVT1, preventing cytosolic mis-segregation and chromosomal integration.