Eléonore Toufektchan

Squamous-state excursions activate APOBEC3A in cancer

The paper identifies transient squamous-state excursions in cancer cells as a source of APOBEC3A mutagenesis, linking it to lineage-state plasticity rather than persistent inflammation.

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

The paper identifies BAF as a barrier that restricts TREX1 access to micronuclei, explaining the need for ER-tethering to enable TREX1 entry and suppress cGAS activation.

Mitotic transcription ensures ecDNA inheritance through chromosomal tethering

The paper shows that ecDNA inheritance is ensured through mitotic transcription and chromosomal tethering via BRD4 and PVT1, preventing cytosolic mis-segregation and chromosomal integration.

TREX1 restricts CRISPR-Cas9 genome editing in human cells

The paper identifies TREX1 as a suppressor of CRISPR-Cas9 HDR efficiency in human cells and shows that TREX1 removal or use of chemically protected templates can enhance HDR.

ER-directed TREX1 limits cGAS recognition of micronuclei

This study shows TREX1 limits cGAS recognition of micronuclear DNA by degrading it after micronuclear envelope rupture, and a TREX1 mutation disrupts this process, enhancing immune sensing.

APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

This study identifies TREX1 and APOBEC3B as key drivers of chromothripsis and kataegis during telomere crisis in cancer.