Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data
Alyssa R. Wenzel, Patrick Haughey, Kyle Nguyen, John T. Nardini, Jason M. Haugh, Kevin Flores
The paper introduces TOPAZ, a framework that uses topological data analysis and Bayesian methods to infer agent-based models from spatiotemporal cellular data, showing it can accurately recover model parameters and distinguish between models.
PLoS Computational Biology · Sep 25, 2026Peer-reviewedCell Biology