Jason M. Haugh

Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data

The paper introduces TOPAZ, a framework that uses topological data analysis and Bayesian methods to infer agent-based models from spatiotemporal cellular data, showing it can accurately recover model parameters and distinguish between models.

A phase field model with stochastic input simulates cellular gradient sensing, morphodynamics, and fidelity of haptotaxis

The paper develops a phase field model to simulate haptotaxis, showing how directional persistence compensates for reduced gradient bias and maintains response robustness in multi-cue environments.

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration

The paper investigates how CD44 and Ezrin restrict EGF receptor mobility to create a spatial signaling gradient that stabilizes bleb-based migration in non-adhesive environments.

Optogenetic control of PLC-γ1 activity directs cell motility

This study shows that local activation of PLC-γ1 via optogenetic tools can direct cell motility, revealing its role in chemotaxis beyond mere signaling.