Kevin Flores

Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data

The paper introduces TOPAZ, a framework that uses topological data analysis and Bayesian methods to infer agent-based models from spatiotemporal cellular data, showing it can accurately recover model parameters and distinguish between models.

A generalized resource-allocation growth law reveals mechanisms of differential responses to intermittent androgen deprivation therapy in prostate cancer

This paper develops a generalized resource-allocation growth law to model prostate cancer responses to intermittent androgen deprivation therapy, showing it predicts treatment outcomes and adapts to different schedules.

P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

This study shows that the p95 isoform of HER2 promotes metastasis by biasing MRTFA-dependent signaling through specific tyrosine phosphorylation.

Looking beyond stereotyped neuron structures reveals links between beading and morphological rearrangements in aging phenotypes.

This study uses automated dendrite tracing and categorization to show that aging and cold shock cause distinct dendritic beading patterns driven by branching history and systemic effects, respectively.

Deep learning-enabled phenotyping reveals distinct patterns of neurodegeneration induced by aging and cold-shock

This study uses deep learning to analyze neurodegeneration patterns in C. elegans neurons, finding distinct effects of aging and cold-shock.