Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival
Alyssa Rivera, William E. Schutzer, Alex Sonneborn, S. Shotwell, Aaron J. Janowsky, Atheir I. Abbas, Randy Torralva
This study shows that combining naloxone with clonidine rescues fentanyl-induced respiratory and cardiovascular failure in rats, improving survival by reopening the airway.
bioRxiv · Nov 7, 2025 · PreprintPharmacology & Toxicology