Aaron J. Janowsky

Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival

This study shows that combining naloxone with clonidine rescues fentanyl-induced respiratory and cardiovascular failure in rats, improving survival by reopening the airway.

Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study

This study shows that specific GPCRs produce unique extracellular vesicle miRNA signatures, which are linked to distinct biological and pathological processes.

Development of novel tools for dissection of central versus peripheral dopamine D2-like receptor signaling in dysglycemia

The paper develops pharmacological tools to selectively target central versus peripheral dopamine D2-like receptors and shows their distinct roles in treating dysglycemia.

Persistent inflammation promotes endocannabinoid release and presynaptic cannabinoid 1 receptor desensitization

This study shows that persistent inflammation reduces presynaptic CB1R function in rats but maintains eCB activation, with implications for pain therapy development.

Trace amine-associated receptor gene polymorphism increases drug craving

The paper investigates the effect of a TAAR1 gene polymorphism on drug craving in individuals with methamphetamine dependence and finds a significant association with increased craving.