Author

Alyssa Semmelman

Columbia University

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Biology Disciplines

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Biochemistry· 1

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Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

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Anne E. van VlimmereniD· 1 shared Deepti KaranduriD· 1 shared Neel H. ShahiD· 1 shared Ziyuan JiangiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiochemistry

Anne E. van VlimmerenORCID

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1 paper

Recent·Most cited

Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity

Ziyuan Jiang, Anne E. van Vlimmeren, Deepti Karandur, Alyssa Semmelman, Neel H. Shah

The paper uses deep mutational scanning to analyze SHP2 mutations, revealing diverse regulatory mechanisms and potential pathogenicity of uncharacterized variants.

Nature Communications · Jul 1, 2025Peer-reviewedBiochemistry