Author

Deepti Karandur

Vanderbilt UniversityORCID 0000-0002-6949-6337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1

Frequent Co-Authors

Anne E. van VlimmereniD· 2 shared John KuriyaniD· 2 shared Neel H. ShahiD· 2 shared Ziyuan JiangiD· 2 shared Alyssa Semmelman· 1 shared Anya T. Applebaum Licht· 1 shared Baiyu QiuiD· 1 shared Darren B. McAffeeiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Anne E. van VlimmerenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Redesign of energetically frustrated regions rescues function in defective T4 clamp loaders

Siddharth Nimkar, Thu Nguyen, Deepti Karandur, Subu K. Subramanian, Mike E. O’Donnell, John Kuriyan

The paper identifies and redesigns energetically frustrated regions in a defective T4 clamp loader to restore function through conformational balance and stability.

Molecular Biology and Evolution · Aug 14, 2026Peer-reviewedBiochemistry

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2

Anne E. van Vlimmeren, Ziyuan Jiang, Deepti Karandur, Anya T. Applebaum Licht, Neel H. Shah

This study identifies a novel active conformation of SHP2 stabilized by the E139D mutation, which alters phosphoprotein binding preferences compared to canonical hyperactive mutants.

Protein Science · Nov 12, 2025Peer-reviewedBiochemistry

Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity

Ziyuan Jiang, Anne E. van Vlimmeren, Deepti Karandur, Alyssa Semmelman, Neel H. Shah

The paper uses deep mutational scanning to analyze SHP2 mutations, revealing diverse regulatory mechanisms and potential pathogenicity of uncharacterized variants.

Nature Communications · Jul 1, 2025Peer-reviewedBiochemistry

Breakage of the Oligomeric CaMKII Hub by the Regulatory Segment of the Kinase

Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia, Young Kwang Lee, Serena Muratcioğlu, Darren B. McAffee, Ethan D. McSpadden, Baiyu Qiu, Jay T. Groves, Evan R. Williams, John Kuriyan

The paper shows that the regulatory segment of CaMKII can break the oligomeric hub into smaller assemblies through binding and structural destabilization.

eLife · Sep 9, 2020Peer-reviewedBioinformatics