Anne E. van Vlimmeren

The paper uses multi-omics approaches to study post-translational changes in macrophages during activation, identifying endosomal mRNA transport as a target of inflammation.

This paper identifies PTP1B substrates using in situ photo-crosslinking, revealing new substrates and interactions, including EGF receptor binding.

This study uses single-cell transcriptomics to analyze how diverse SHP2 variants affect gene expression and cellular phenotypes in relation to disease.

This study uses proximity-labeling proteomics to analyze how SHP2 mutations alter its interactome and localization, revealing functional consequences of different mutation types.

This study identifies a novel active conformation of SHP2 stabilized by the E139D mutation, which alters phosphoprotein binding preferences compared to canonical hyperactive mutants.

The paper uses deep mutational scanning to analyze SHP2 mutations, revealing diverse regulatory mechanisms and potential pathogenicity of uncharacterized variants.

This paper shows that Grb2 binding to PTP1B allosterically enhances its catalytic activity through structural changes, revealing a new regulatory mechanism for PTP1B in cell signaling.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.