High-Density Wild-Type IL-2 Nanoparticles Preferentially Enhance CD8⁺ T-Cell Expansion and Reprogram the Tumor Microenvironment
Ruijie Wang, Pramod Kumar, Noah A. Crumrine, Tongchatra Watcharawittayakul, Alyssa Wallstrum, Moataz M. Reda, Gordon Mills, Worapol Ngamcherdtrakul, Wassana Yantasee
This paper develops IL2-NP nanoparticles that enhance CD8 T-cell expansion and reprogram the tumor microenvironment, showing efficacy in multiple cancer models.
bioRxiv · Jul 15, 2026 · PreprintBioengineering