Mitochondrial phosphate carrier-dependence of mitochondrial calcium chelation and respiration in skeletal muscle
César Vásquez-Trincado, Valentina Debattisti, Arijita Ghosh, Amanda H Collins, Ji In Han, Carmen Bekeová, Emanuele Loro, Tejvir S. Khurana, György Hajnóczky, Erin L. Seifert
This study shows that mitochondrial phosphate carrier (PiC) depletion increases matrix Ca2+ uptake and alters exercise performance in mice.
bioRxiv · Aug 4, 2026 · PreprintBiochemistry