The Aorta-Gonad-Mesonephros niche shapes the functions of yolk sac-derived macrophages involved in hematopoietic stem and progenitor cell generation ex vivo
Rebecca L. Belmonte, Marianna Romano, Anna Popravko, Amanda MacCallum, Samidha Kulkarni, Malgorzata Rumowska, Cristiana Barone, Alessandro Muratore, Ella E Blanks, Hena Modha, Subhankar Mukhopadhyay, Emanuele Azzoni, Siamon Gordon, Samanta Antonella Mariani
This study identifies niche-specific roles of AGM macrophages in supporting HSPC generation ex vivo, highlighting F4/80's regulatory function and macrophage-derived factors.
bioRxiv · Jul 3, 2026 · PreprintDevelopmental Biology