This study identifies niche-specific roles of AGM macrophages in supporting HSPC generation ex vivo, highlighting F4/80's regulatory function and macrophage-derived factors.

bioRxiv · Jul 3, 2026 · PreprintDevelopmental Biology

Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.

Mark C. Howard, Conrad A. Farrar, Christopher L. Nauser, Yusun Jeon, Anastasia Polycarpou, Dorota Smolarek, Roseanna Greenlaw, Martyn Foster, Peter Garred, Daniela A Vizitiu, Subhankar Mukhopadhyay, Steven Howard Sacks

This study shows that collectin-11 regulates osteoclastogenesis and bone maintenance through complement-dependent mechanisms, with combined deficiencies causing bone loss and spinal curvature in mice.

Proceedings of the National Academy of Sciences · Mar 3, 2026Peer-reviewedImmunology

Shared genetic effects on chromatin and gene expression reveal widespread enhancer priming in immune response

Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, Andrew J. Knights, Alice Mann, Kousik Kundu, Christine Hale, Gordon Dougan, Daniel J. Gaffney

The paper identifies genetic effects on chromatin and gene expression in immune response conditions, revealing enhancer priming in naive cells.

Nature Genetics · Jan 29, 2018Peer-reviewedGenomics

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

Kaur Alasoo, Fernando Martinez Estrada, Christine Hale, Siamon Gordon, Fiona Powrie, Gordon Dougan, Subhankar Mukhopadhyay, Daniel Gaffney

The paper compares transcriptomes of macrophages derived from monocytes and iPSCs to identify conserved and novel LPS responses.

bioRxiv · Jun 25, 2015Immunology