Emanuele Azzoni

Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity

The paper identifies a Runx1 enhancer that distinguishes hematopoietic stem cells (HSCs) from progenitor cells (HPCs) in the mouse dorsal aorta using enhancer-reporter models and single-cell multiome analysis.

The Aorta-Gonad-Mesonephros niche shapes the functions of yolk sac-derived macrophages involved in hematopoietic stem and progenitor cell generation ex vivo

This study identifies niche-specific roles of AGM macrophages in supporting HSPC generation ex vivo, highlighting F4/80's regulatory function and macrophage-derived factors.

MICROGLIAL EXTRACELLULAR VESICLES MEDIATE C1Q DEPOSITION AT THE PRE-SYNAPSE AND PROMOTE SYNAPTIC PRUNING

This study shows that microglial extracellular vesicles deliver C1q to presynaptic sites, promoting synaptic pruning and linking vesicle release to synaptic remodeling.

Hemogenic endothelium of the vitelline and umbilical arteries is the major contributor to mouse fetal lympho-myelopoiesis

The paper identifies hemogenic endothelium in vitelline and umbilical arteries as a major source of fetal lympho-myeloid progenitors in mice, showing their transient contribution before definitive HSCs emerge.

Spatiotemporal dynamics of cytokines expression dictate fetal liver hematopoiesis.

The paper identifies the spatiotemporal dynamics of cytokine expression in fetal liver hematopoiesis, showing that hepatoblasts and mesothelial cells produce key growth factors and cytokines.

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition

The paper shows that SET levels influence enhancer usage during cell fate acquisition, leading to altered gene regulation and contributing to disease.