Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas
Alice Recho, Himavanth Reddy Gatla, Erin E. Resch, Maggie J. Phillips, Stephanie A. Glavaris, Michele Doucet, Amanda N. M. Looi, Michael I. Barbato, Nicolas Jose Llosa, Michael A. Koldobskiy, Brian H. Ladle
This study shows that combining decitabine and entinostat increases immunogenicity of low-mutation sarcomas by upregulating antigens and enhancing T cell responses.
bioRxiv · Jun 21, 2026 · PreprintImmunology