Rational redesign of antigen binding domain improves in vivo efficacy of CD22-CAR T cells
Kole DeGolier, Zachary H. Walsh, Lillie Leach, Christine R. Brzezinski, Amanda Novak, Dimiter Dmitrov, Mark Eric Kohler, Terry J. Fry
This study improves the in vivo efficacy of CD22-targeted CAR T cells by optimizing the balance between binding affinity and tonic signaling through rational redesign of the antigen binding domain.
bioRxiv · Mar 13, 2025 · PreprintImmunology