Author

Mark Eric Kohler

Children's Hospital ColoradoORCID 0000-0002-1181-0418Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Amanda Novak· 1 shared Christine R. Brzezinski· 1 shared Dimiter Dmitrov· 1 shared Kole DeGolieriD· 1 shared Lillie Leach· 1 shared Terry J. FryiD· 1 shared Zachary H. WalshiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Amanda Novak

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintMar 13, 2025

Rational redesign of antigen binding domain improves in vivo efficacy of CD22-CAR T cells

Kole DeGolier, Zachary H. Walsh, Lillie Leach…·Terry J. Fry

This study improves the in vivo efficacy of CD22-targeted CAR T cells by optimizing the balance between binding affinity and tonic signaling through rational redesign of the antigen binding domain.

DOI 10.1101/2025.03.13.643183

humanexperimental assay

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