Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer
Maximilian Mossner, Chloé Colson, Qingli Guo, Frederick J.H. Whiting, Heather E. Grant, Amanda Stafford, Peter Kyle, Daniella Donato‐Brown, Jamie Murphy, Andrea Sottoriva, Ann‐Marie Baker, Trevor A. Graham
This paper introduces dATAC, a single-cell multi-omic method for simultaneous whole genome sequencing and chromatin accessibility profiling, revealing genome-epigenome coevolution in colorectal cancer.
bioRxiv · Apr 15, 2025 · PreprintMolecular Biology