Qingli Guo

This paper introduces dATAC, a single-cell multi-omic method for simultaneous whole genome sequencing and chromatin accessibility profiling, revealing genome-epigenome coevolution in colorectal cancer.

This paper identifies long deletion signatures in repetitive regions as markers of microsatellite instability and develops a classifier to detect MSI in low-quality sequencing data.

This paper identifies mutational signatures caused by formalin fixation and introduces FFPEsig, a method to correct these artefacts in genome sequencing data.