Neuronal lipid composition regulates distinct states of full-length tau assembly, mechanics and membrane interactions
Amaresh Kumar Mahakud, Aninda Sundar Modak, Snehasikta Singh, Vaishnavi Ananthanarayana, Hariharakrishnan Chidamabaram, Swagata Ghatak, Subashchandrabose Chinnathambi, Mohammed Saleem
This study shows how neuronal lipid composition affects full-length tau assembly, mechanics, and membrane interactions, revealing distinct states of tau-membrane interaction based on lipid type and tau assembly state.
bioRxiv · Sep 18, 2026 · PreprintBiophysics