Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer's disease-resilience spectrum
Helen A. Jolly, Paula Seghers, Kaleah Balcomb, Amelia J. Smith, Laura Pearson, Ishan Agrawal, Bethany Geary, David Alan Bennett, Thomas Wısnıewskı, Stephanie L. Fowler, Eleanor Drummond, Oliver M. Crook, Becky Catherine Carlyle
The paper uses subcellular proteomics to identify disease-associated protein localization shifts in Alzheimer's disease across the resilience spectrum, revealing insights beyond abundance-based proteomics.
bioRxiv · Aug 21, 2026 · PreprintNeuroscience