Bethany Geary

Population-scale subcellular proteomics reveals intracellular remodelling across the Alzheimer's disease-resilience spectrum

The paper uses subcellular proteomics to identify disease-associated protein localization shifts in Alzheimer's disease across the resilience spectrum, revealing insights beyond abundance-based proteomics.

Mononuclear myeloid cells mount an adaptive protective response to intracerebral haemorrhage by activation of NRF2

The paper identifies NRF2 activation in mononuclear myeloid cells as a protective response to intracerebral haemorrhage, showing its therapeutic potential through modulation of interferon pathways.

New Human IPSC Models of Late-onset Alzheimer's Disease Polygenic Risk Identify Multiple Impairments of Microglial Function

This study uses human iPSC-derived microglia with high polygenic AD risk to identify functional impairments in immune response, mitochondrial function, and amyloid-beta uptake.

Temporal Interference Stimulation Enhances Neural Regeneration

This study shows that temporal interference stimulation enhances neural progenitor cell maturation in vitro and promotes hippocampal neurogenesis in a mouse Alzheimer's model.

Brain-derived neurotrophic factor amplifies neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

This study shows BDNF enhances axonal regeneration in human motor neurons by regulating RNA metabolism and cytoskeletal dynamics through kinase pathways.

Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In vitro

The paper introduces an open platform for creating functional cortical circuits using iPSC-derived neurons, enabling controlled network assembly and analysis of synaptic activity and connectivity.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

The paper identifies tau filaments within extracellular vesicles from Alzheimer's disease patients using mass spectrometry and cryo-electron microscopy.

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons

The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.